Curvy surface conformal ultra-thin transfer printed Si optoelectronic penetrating microprobe arrays

Penetrating neural probe arrays are powerful bio-integrated devices for studying basic neuroscience and applied neurophysiology, underlying neurological disorders, and understanding and regulating animal and human behavior. This paper presents a penetrating microprobe array constructed in thin and flexible fashion, which can be seamlessly integrated with the soft curvy substances. The function of the microprobes is enabled by transfer printed ultra-thin Si optoelectronics. As a proof-of-concept device, microprobe array with Si photodetector arrays are demonstrated and their capability of mapping the photo intensity in space are illustrated. The design strategies of utilizing thin polyimide based microprobes and supporting substrate, and employing the heterogeneously integrated thin optoelectronics are keys to accomplish such a device. The experimental and theoretical investigations illustrate the materials, manufacturing, mechanical and optoelectronic aspects of the device. While this paper primarily focuses on the device platform development, the associated materials, manufacturing technologies, and device design strategy are applicable to more complex and multi-functionalities in penetrating probe array-based neural interfaces and can also find potential utilities in a wide range of bio-integrated systems

Fully rubbery integrated electronics from high effective mobility intrinsically stretchable semiconductors

An intrinsically stretchable rubbery semiconductor with high mobility is critical to the realization of high-performance stretchable electronics and integrated devices for many applications where large mechanical deformation or stretching is involved. Here, we report fully rubbery integrated electronics from a rubbery semiconductor with a high effective mobility, obtained by introducing metallic carbon nanotubes into a rubbery semiconductor composite. This enhancement in effective carrier mobility is enabled by providing fast paths and, therefore, a shortened carrier transport distance. Transistors and their arrays fully based on intrinsically stretchable electronic materials were developed, and they retained electrical performances without substantial loss when subjected to 50% stretching. Fully rubbery integrated electronics and logic gates were developed, and they also functioned reliably upon mechanical stretching. A rubbery active matrix based elastic tactile sensing skin to map physical touch was demonstrated to illustrate one of the applications

Wearable Devices for Single-Cell Sensing and Transfection

Wearable healthcare devices are mainly used for biosensing and transdermal delivery. Recent advances in wearable biosensors allow for long-term and real-time monitoring of physiological conditions at a cellular resolution. Transdermal drug delivery systems have been further scaled down, enabling wide selections of cargo, from natural molecules (e.g., insulin and glucose) to bioengineered molecules (e.g., nanoparticles). Some emerging nanopatches show promise for precise single-cell gene transfection in vivo and have advantages over conventional tools in terms of delivery efficiency, safety, and controllability of delivered dose. In this review, we discuss recent technical advances in wearable micro/nano devices with unique capabilities or potential for single-cell biosensing and transfection in the skin or other organs, and suggest future directions for these fields. Highlights • Current wearable sensors have allowed for long-term, real-time detection of specific biomarkers directly from patients. • Miniaturized wearable biosensors with sensing elements interacting with skin or organs can capture target molecules from single cells, which results in significantly increased sensitivity, responding time, and precision. • Emerging wearable devices based on novel nanomaterials or nanofabrication show potential for single-cell detection in cancer cell screening, cardiomyocyte detection, and optogenetics. • Transdermal delivery devices have been scaled down to the micro- and/or nanoscale, and their applications have extended to wide selections of natural molecules and bioengineered molecules. • Emerging nanodevices show unique capabilities in precise single-cell gene transfection in vivo, with improved delivery efficiency, safety, and dose controllability

Metal oxide semiconductor nanomembrane-based soft unnoticeable multifunctional electronics for wearable human-machine interfaces

Wearable human-machine interfaces (HMIs) are an important class of devices that enable human and machine interaction and teaming. Recent advances in electronics, materials, and mechanical designs have offered avenues toward wearable HMI devices. However, existing wearable HMI devices are uncomfortable to use and restrict the human body's motion, show slow response times, or are challenging to realize with multiple functions. Here, we report sol-gel-on-polymer-processed indium zinc oxide semiconductor nanomembrane-based ultrathin stretchable electronics with advantages of multifunctionality, simple manufacturing, imperceptible wearing, and robust interfacing. Multifunctional wearable HMI devices range from resistive random-access memory for data storage to field-effect transistors for interfacing and switching circuits, to various sensors for health and body motion sensing, and to microheaters for temperature delivery. The HMI devices can be not only seamlessly worn by humans but also implemented as prosthetic skin for robotics, which offer intelligent feedback, resulting in a closed-loop HMI system

Stretchable elastic synaptic transistors for neurologically integrated soft engineering systems

Artificial synaptic devices that can be stretched similar to those appearing in soft-bodied animals, such as earthworms, could be seamlessly integrated onto soft machines toward enabled neurological functions. Here, we report a stretchable synaptic transistor fully based on elastomeric electronic materials, which exhibits a full set of synaptic characteristics. These characteristics retained even the rubbery synapse that is stretched by 50%. By implementing stretchable synaptic transistor with mechanoreceptor in an array format, we developed a deformable sensory skin, where the mechanoreceptors interface the external stimulations and generate presynaptic pulses and then the synaptic transistors render postsynaptic potentials. Furthermore, we demonstrated a soft adaptive neurorobot that is able to perform adaptive locomotion based on robotic memory in a programmable manner upon physically tapping the skin. Our rubbery synaptic transistor and neurologically integrated devices pave the way toward enabled neurological functions in soft machines and other applications

Research on Event-driven Data Collection Protocol of Wireless Sensor Networks

This paper carries out research on two types of event-driven data collection protocols of wireless sensor networks: EDDGP and ACBP protocols. In the EDDGP protocol, an adaptive evaluation model is put forward to select the cluster head, including the node classification, the fuzzy grade classification, the evaluation function and the parent grid resolution. Once an event of interest occurs, the member nodes will send the collected information to the cluster heads which will then integrate the data and send a request packet for data collection to the sink. After receiving the request packet, the sink will quickly move to the cluster head for collecting information. If the sink receives the request packet for data collection from other cluster heads of information source in the moving process, it will save their grid ID. The data from the other cluster heads of information source are collected in turn from the nearest ones to the farthest ones. The theoretical research and simulation results show that EDDGP can reduce the energy consumption of location updates of the sink so as to balance the energy consumption of nodes and prolong the lifetime of the network